基本情况:
李忠贞,广东茂名人,1990年11月生,理学博士,副教授(校内聘)。
联系方式:电子邮箱:960510784@qq.com
教育背景:
2009.09-2013.06 广东工业大学,生物工程专业,获工学学士学位
2013.09-2019.06 汕头大学,海洋生物学专业,获理学博士学位
工作经历:
2019.07-2021.06,暨南大学,临床医学博士后科研流动站,博士后
2021.07-2024.10,珠海市人民医院,博士后科研工作站,博士后
2024.10至今 广东石油化工学院,生物与食品工程学院,内聘副教授
研究方向:
主要从事动物肠道微生物、益生菌、益生元方面的工作。
讲授课程:
本科生:微生物学
学术兼职:
无。
主要获奖(自己获奖或指导学生获奖):
第一届广东省免疫学会“普锐杯”科普比赛博士后组一等奖,2020年;
汕头大学第十四届研究生学术论坛优秀论文奖,2018年;
广东省大学生实验室安全与环保知识竞赛优胜奖,2011年;
承担项目:
1. 国家自然科学基金青年科学基金项目(编号:32200079),迟缓埃格特菌诱导焦虑抑郁行为的作用机制及靶向干预研究,2023.01-2025.12,负责人,在研。
2. 国家自然科学基金面上项目(编号:32070121),锰缺乏通过肠道菌群失衡介导抑郁症及其分子机制,2021.01-2024.12,参与人,在研。
3. 国家自然科学基金面上项目(编号:41876152),ECSIT介导的线粒体ROS途径在拟穴青蟹血淋巴菌群稳态调控中的作用及分子机制,2019.01-2022.12,参与人,结题。
4. 国家自然科学基金面上项目(编号:41641053),拟穴青蟹肠道菌群抗病毒感染及其分子机理研究,2017.01-2017.12,参与人,结题。
代表性成果:
1. Li Zhongzhen#, Lei Zhiwei#, Yang Wanying, Jing Chunxia, Sun Xiaolin, Yang Guang, Zhao Xiaozhen, Zhang Mingjiao, Xu Miaomiao, Tang Yuanjia, Wang Qingwen, Zhao Jing, Zhou Zixing, Wen Zihao, Chen Xiaojing, Peng Qinglin, Wang Guochun, Zhang Pingjing, Sun Erwei, Shen Nan, Xu Weiguo*, Li Zhanguo, Yang Hengwen*, Yin Zhinan*. Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus. Parasites & Vectors, 2024, 17(1): 44.
2. Li Zhongzhen, Tran Ngoc Tuan, Ji Peina, Sun Zaiqiao, Wen Xiaobo, Li Shengkang*. Effects of prebiotic mixtures on growth performance, intestinal microbiota and immune response in juvenile chu's croaker, Nibea coibor. Fish & Shellfish Immunology, 2019, 89: 564-573.
3. Li Zhongzhen, Zhang Xinxu, Aweya Jude Juventus, Wang Shuqi, Hu Zhong, Li Shengkang*, Wen Xiaobo. Formulated diet alters gut microbiota compositions in marine fish Nibea coibor and Nibea diacanthus. Aquaculture Research, 2018, 50(1): 126-138.
4. Yan Junjie#, Zeng Yingying#, Guan Zerong#, Li Zhenhua#, Luo Shunchang#, Niu Jie#, Zhao Junzhang#, Gong Haibiao, Huang Ting, Li Zhongzhen, Deng Anyi, Wen Qiong, Tan Jingyi, Jiang Jun, Bao Xiucong, Li Sitao, Sun Guodong, Zhang Min, Zhi Min*, Yin Zhinan*, Sun Wan-Yang*, Li Yi-Fang*, He Rong-Rong*, Cao Guangchao*. Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Reports, 2024, 43(8): 114636.
5. Zhang Ming, Ji Peina, Li Zhongzhen, Sun Zaiqiao, Tran Ngoc Tuan, Li Shengkang*. Catalase regulates the homeostasis of hemolymph microbiota and autophagy of the hemocytes in mud crab (Scylla paramamosain). Aquaculture Reports, 2022, 25: 101237.
6. Tran Ngoc Tuan, Li Zhongzhen, Ma Hongyu, Zhang Yueling, Zheng Huaiping, Gong Yi, Li Shengkang*. Clostridium butyricum: a promising probiotic confers positive health benefits in aquatic animals. Reviews in Aquaculture, 2020, 12(4): 2573-2589.
7. Tran Ngoc Tuan; Tang Yong; Li Zhongzhen, Zhang Ming, Wen Xiaobo, Ma Hongyu, Li Shengkang*. Galactooligosaccharides and resistant starch altered microbiota and short-chain fatty acids in an in vitro fermentation study using gut contents of mud crab (Scylla paramamosain). Frontiers in Microbiology, 2020, 11: 1352.
8. Yang Qiuhua, Lü Yongling, Zhang Ming, Gong Yi, Li Zhongzhen, Tran Ngoc Tuan, He Yüyong, Zhu Chunhua, Lu Yishan, Zhang Yueling, Li Shengkang*. Lactic acid bacteria, Enterococcus faecalis Y17 and Pediococcus pentosaceus G11, improved growth performance, and immunity of mud crab (Scylla paramamosain). Fish & Shellfish Immunology, 2019, 93: 135-143.
9. Tran Ngoc Tuan, Li Zhongzhen, Wang Shuqi, Zheng Huaiping, Aweya Jude Juventus, Wen Xiaobo, Li Shengkang*. Progress and perspectives of short‐chain fatty acids in aquaculture. Reviews in Aquaculture, 2018, 12(1): 283-298.
10. Zhang Xinxu, Wu Huijuan, Li Zhongzhen, Li Yuanyou, Wang Shuqi, Zhu Dashi, Wen Xiaobo, Li Shengkang*. Effects of dietary supplementation of Ulva pertusa and non-starch polysaccharide enzymes on gut microbiota of Siganus canaliculatus. Journal of Oceanology and Limnology, 2017, 36(2): 438-449.
11. Sun Wanwei, Li Zhongzhen, Wang Shasha, Wan Weisong, Wang Shuqi, Wen Xiaobo, Zheng Huaiping, Zhang Yueling, Li Shengkang*. Identification of a novel clip domain serine proteinase (Sp-cSP) and its roles in innate immune system of mud crab Scylla paramamosain. Fish & Shellfish Immunology, 2015, 47(1): 15-27.
12. Wu Huijuan, Sun Lingbin, Li Chuanbiao, Li Zhongzhen, Zhang Zhao, Wen Xiaobo, Hu Zhong, Zhang Yueling, Li Shengkang*. Enhancement of the immune response and protection against Vibrio parahaemolyticus by indigenous probiotic Bacillus strains in mud crab (Scylla paramamosain). Fish & Shellfish Immunology, 2014, 41(2): 156-162.
13. 李升康, 李忠贞, 孙再桥, 黎照熙. 一株具有益生活性的产丁酸菌DG1及其培养方法与应用, 授权发明专利, ZL201910361921.3, 2022/12/20.
14. 李升康, 李忠贞, 纪培娜, 张明. 一株具有益生活性的丁酸梭菌CG3及其培养方法与应用, 授权发明专利, ZL201910361908.8, 2022/12/6.
15. 李升康, 吕永玲, 李忠贞, 刘文华, 胡忠, 温小波. 一株粪肠球菌Y17及其筛选培养与应用, 授权发明专利, ZL201610547932.7, 2019/9/13.
16. 李升康, 吕永玲, 李忠贞, 刘文华, 胡忠, 温小波. 一株戊糖片球菌G11及其筛选与应用, 授权发明专利, ZL201610547940.1, 2019/9/13.