基本情况
姓名:李桂银
性别:女
出生年月:1972-10
籍贯:湖南省
职位:博士
职称:教授
联系方式
电话:18607732676
传真:暂无资料
邮箱:liguiyin01@gdupt.edu.cn
通讯地址: 广东省茂名市广东石油化工学院化学学院
邮编:525000
个人网站:
教育经历
2004年-2008年中南大学化学化工学院功能材料所,获工学博士学位;
2001年-2004年中南大学化学化工学院,获理学硕士学位;
1992年-1995年邵阳学院化工工艺专业,获理学学士学位。
工作经历
2021.09-至今,广东石油化工学院化学学院二级教授,学科带头人
2010.10-2021.09,桂林电子科技大学生命与环境科学学院教授
2015.06-2016.07,University of Michigan, Biomedical Engineering, Visiting Scholar
2014.01-2018.12,广西医科大学生物靶向诊治中心临床医学博士后
2013.01-2014.01, 桂林电子科技大学生命与环境科学学院副院长
2008.12-2010.09,中南大学药学院药学博士后流动站药学博士后
2004.04-2010.09, 湖南科技职业学院轻化工程学院副教授
讲授课程
《化妆品生产工艺学》,本科;
《精细化工概论》,本科;
《生物医学传感与检测原理》,本科;
《药理学(英文教材)》,本科;
《药物化学》,本科;
《生物材料》,本科;
《生物力学》,本科;
《生物信息学数据挖掘》,本科;
《微生物与免疫学》,本科;
《生物材料》,研究生;
《高等分子生物学》,研究生;
《医学检验原理》,研究生。
科研方向
1. 重大疾病标记物的血清学检测
2. 稀(贵)金属的富集与去除
3. 生物医学传感
4. 纳米靶向药物的构筑与评价
科研项目
1. 国家自然科学基金,硼氮掺杂碳点/二硫化钼基纳米酶荧光-电化学双模同步逻辑传感平台检测肝癌标志物研究(62371143)2024-2027,主持,在研。
2. 广东石油化工学院高层次人才引进项目,荧光-电化学双信号传感检测GP73的研究(RC-XJ2022000401),2022-2027,主持,在研。
3. 国家自然科学基金,基于石墨烯的GPC3适配体纳米生物传感器靶向诊断肝癌的研究(81760534),2018-2021,主持,结题。
4. 广西壮族自治区科学技术厅, 广西重点研发计划(桂科AB18281013), 柿单宁提取制粉技术与重(贵)金属捕集剂的研制与应用示范, 2019-2022, 160万元, 子课题负责人,结题。
5. 国家自然科学基金,近红外荧光/磁性Endoglin适配体靶向肺癌双模态成像研究(81460451),2015-2018,主持,结题。
6. 广西自然科学基金,柿单宁/石墨烯/Pt-Pd无酶血糖传感器研究(2016GXNSFAA380080),2016- 2019,主持,结题。
7. 中国博士后科学基金,基于Endoglin靶的光/磁探针用于肝癌多模态成像研究(2013M531916),2014-2016,主持,结题。
8. 广西科技厅科学计划与研究项目,柑桔果皮黄酮类及辛弗林生物活性物质高校提取关键技术研究(桂科转1412200813),2014-2016,主持,结题。
9. 广西科技厅科学计划与研究项目,一种治疗骨质增生、椎间盘突出的外敷药的稳定化研究(桂科攻12300011),2012-2016,主持,结题。
10. 国家自然科学基金重点项目,特异性适配体生物传感器靶向诊断肝癌的新技术研究 (81430055),2015-2019,主要参与,结题。
获奖情况
1. 广西科学技术进步奖三等奖,超低成本五分类血细胞分析仪的研制,2020年;
2. 广西医药卫生适宜技术推广奖二等奖,基于哑铃型Au-Fe3O4纳米材料的生物传感方法构建及其临床应用,2019年;
3. 广西科学技术进步奖三等奖,基于磁纳米金的生物传感方法构建及其临床应用, 2019年;
4. 广西科技技术发明奖三等奖,柿单宁提取制粉技术及功能化应用,2018年;
5. 桂林电子科技大学生物医学学科学术带头人,2014年;
6. 广西高等教育自治区教学成果奖,广西高等教育自治区教学成果奖,校级,2012年;
7. 桂林电子科技大学学术骨干,2011年;
8. 湖南省“芙蓉百岗明星”,湖南省总工会,2009年;
9. 湖南省普通高校中青年骨干教师,湖南教育厅,2008年。
论著一览(2022-2023)
[1] Li Guiyin, Li Shengnan, Huang Qing, Li Xinhao, Zhang Zhengyu, Liang Jintao*, Zhou Zhide*. Rapid and specific detection of LDL based on light addressable potentiometric sensor decorated with reduced graphene oxide-polyaniline-hemin nanocomposites, Microchemical Journal 194 (2023) 109314.
[2] Li Guiyin, Li HaiMei, Li Xinhao, Huang Huapeng, Bian Huimin*, Liang Jintao*, Zhou Zhide*. A label-free electrochemical aptasensor for low-density lipoprotein detection using MoS2-Au-Fc nanosheets as a high-performance redox indicator, Microchemical Journal 193 (2023) 109068.
[3] Li Guiyin, Zhou Zhide, Wang Zhongmin, Chen hiwei, Liang Jintao, Yao Xiaoqing, Li Liuxun. An Efficient Electrochemical Biosensor to Determine 1,5-Anhydroglucitol with Persimmon-Tannin-Reduced Graphene Oxide-PtPd Nanocomposites, Materials, 16 (2023) 2786
[4] Li Guiyin,Wang Bo, Li Ling, Li, Xinhao, Yan Ruijie, Liang Jintao, Zhou Xinchun, Li Liuxun, Zhou Zhide. H-rGO-Pd NPs nanozyme enhanced silver deposition strategy for electrochemical detection of glypican-3, Molecules 28(5) (2023) 2271
[5] Liang Jintao, Yan Ruijie, Chen Chunguan, Yao Xiaoqing, Guo Fei, Wu Runqiang, Zhou Zhide*, Chen Jiejing*. Li Guiyin*. A novel fluorescent strategy for Golgi protein 73 determination based on aptamer/nitrogen-doped graphene quantum dots/molybdenum disulfide @ reduced graphene oxide nanosheets, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 294 (2023) 122538
[6] Liang Jintao, Yan Kaiteng, LiuYutong,Yao Xiaoqing, Guo Fei, Xue Wen, Li Guiyin*, Chen Jiejing*, Zhou Zhide*. A rGO-PAM-Fc/AuNPs nanosensing membrane in a light-addressable potentiometric biosensor for 1,5-anhydroglucitol determination, Microchemical Journal, 184 (2023) 108185.
[7] Wang Zhongmin, Liu Zhigao,Wu Chenxi, Liu Songlin, Wang Dianhui, Hu Chaohao, Chen Tao, Ran Zhaojin*, Gan Weijiang*, Li Guiyin*. Computational Analysis on Antioxidant Activity of Four Characteristic Structural Units from Persimmon Tannin, Materials, 16 (2023) 320
[8] Sun Xinjun, Fang Fengyan, Na Jintong, Yan Runjie, Huang Yong, Zhou Zhide*, Zhao Yongxiang*, Li Guiyin*, Fluorescent "turn-on" aptamer sensor for sensitive and reliable detection of Golgi glycoprotein 73 based on nitrogen-doped graphene quantum dots and molybdenum disulfide nanosheets, Journal of Pharmaceutical and Biomedical Analysis, 225 (2023) 115215
[9] Li Guiyin, Li Haimei, Wang Chaoxian, Li Xinhao, Chen Jiejing*, Liang Jintao*, and Zhou Zhide*. Colorimetric Aptasensor for Sensitive Glypican-3 Detection Based on Hemin-Reduced Oxide Graphene-Platinum@Palladium Nanoparticles With Peroxidase-Like Activity, IEEE Sensors Journal, 2023, 23 (1): 111-118 .
[10] Liang Jintao, Guo Fei, Huang Jiaying, Tan Xiaohong, Sun Lixian*, Zhou Zhide*, Li Guiyin*. An ultrasensitive label-free electrochemical aptasensing platform for Golgi protein-73 detection based on RGO-Fc-Mn3O4 nanocomposites, Microchemical Journal, 193 (2023) 109138.
[11] Zhou Fan, Gao Lin, Cu Shunyan, Tian Jing, Wang Tong, Li Guiyin, Wang Zhongmin, Qin Chaoke, Lin Dahong, Gan Weijiang*, Ran Zhaojin. Exploring the potential of magnetic persimmon tannins-based bio-adsorbent for Cd (II) ions removal from water: Experiment and DFT study, Journal of Water Process Engineering, 56 (2023) 104283.
[12] Li Guiyin, Wu Guangxiong, Yan Ruijie, Li XinHao, Liang Jintao*, Tan Mingxiong*. Zhou Zhide*. Carbon-based light addressable potential sensor based on nitrogen-doped graphene quantum dots for detection of low-density lipoprotein, Microchemical Journal, 196 (2024) 109556.
[13] Liang Jintao, Wu Liang, Wang Liru, Li Guiyin, Zhang Tie, Zhang Yonghuai, and Zhang Jiayang. Determination of difluoromethane (R32) by non-dispersive infrared (NDIR) spectroscopy with temperature compensation by an improved whale optimization algorithm (IWOA), Instrumentation Science & Technology (2023).
2022年
[1] Li Guiyin, Li Wenzhan, Li Shengnan, Li Xinhao,Yao Xiaoqing, Xue Wen, Liang Jintao*, Chen Jiejing*, Zhou Zhide*. A label-free electrochemical aptasensor based on platinum@palladium nanoparticles decorated with hemin-reduced graphene oxide as a signal amplifier for glypican-3 determination, Biomaterials Science, 10 (2022) 6804-6817
[2] Li Guiyin, Xue Yewei, Wang Chaoxian, Li Xinhao, Li Shengnan, Huang Yong*, Zhou Zhide*. Persimmon Tannin-Reduction Graphene Oxide-Platinum-Palladium Nanocomposite Decorated on Screen-Printed Carbon Electrode for Enhanced Electrocatalytic Reduction of Hydrogen Peroxide, Journal of Biomedical Nanotechnology, 18 (2022) 1468-1480
[3] Liu Zhigao,Wang Zhongmin, Gan Weijiang, Liu Songlin, Zhang Jianglin, Ran Zhaojin,Wu Chenxi, Hu Chaohao,Wang Dianhui, Chen Tao, Li Guiyin*. Computational and Experimental Investigation of the Selective Adsorption of Indium/Iron Ions by the Epigallocatechin Gallate Monomer. Materials, 15 (2022) 8251
[4] Xinhao Li,Shengnan Li, Qiuyan Lv,Chaoxian Wang, Jintao Liang*, Zhide Zhou*, Guiyin Li*. Colorimetric biosensor for visual determination of Golgi protein 73 based on reduced graphene oxide-carboxymethyl chitosan-Hemin/platinum@palladium nanozyme with peroxidase-like activity, Microchimica Acta, 189 (2022) 392
[5] Li Guiyin, Chen Wei, Mi Danhong, Wang Bo, Li HaiMei, Wu Guangxiong, Ding Ping*, Liang Jintao*, Zhou Zhide*. A highly sensitive strategy for glypican-3 detection based on aptamer/gold carbon dots/magnetic graphene oxide nanosheets as fluorescent biosensor, Analytical and Bioanalytical Chemistry, 414 (2022):6441-6453
[6] Li Guiyin,Wu Guangxiong, Huang Jindan,Wang Bo, Li HaiMei, Chen Wei, Liang Jintao*,Tan Mingxiong*, Zhou Zhide*. Nanozyme-mediated cascade reaction system for electrochemical detection of 1,5-anhydroglucitol, Bioelectrochemistry, 147 (2022) 108204
[7] Li Shengnan, Li Xinhao, Cao Liping, Wang Chaoxian, Liang Jintao*, Zhou Zhide*, Li Guiyin*. An Ultrasensitive Glypican‑3 Electrochemical Aptasensor Based on Reduced Graphene Oxide-Carboxymethylchitosan -Hemin/Palladium Nanoparticles, Journal of the Electrochemical Society, 169 (2022) 087517
[8] Li Guiyin, Wang Bo, Le Zhao, Shi Xiaohang, Wu Guangxiong, Chen Wei, Sun Lixian*, Liang Jintao*, Zhou Zhide*, Label-free detection of glypican-3 using reduced graphene oxide /polyetherimide/gold nanoparticles enhanced aptamer specific sensing interface on light-addressable potentiometric sensor, Electrochim Acta, 426 (2022) 140808
[9] Li Guiyin,Chen Min,Wang Bo,Wang Chaoxian,Wu Guanxiong,Liang Jintao*, Zhou Zhide*, Dual-signal sandwich-type aptasensor based on H-rGO-Mn3O4 nanozymes for ultrasensitive Golgi protein 73 determination. Analytica Chimica Acta, (1221) 2022, 340102
[10] Wang Huixue, Liu Jinya, Chen Wei, Na Jintong, Huang Yong*, Li Guiyin*, A fluorescence aptasensor based on GSH@GQDs and RGO for the detection of Glypican-3, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 270 (2022) 120798